From BiblePortal Wikipedia

Webster's Dictionary [1]

(1): ( v. i.) To close; to end; to terminate; to turn out; as, we know not how the cause will issue.

(2): ( v. i.) In pleading, to come to a point in fact or law, on which the parties join issue.

(3): ( v. t.) To send out; to put into circulation; as, to issue notes from a bank.

(4): ( v. i.) To be produced as an effect or result; to grow or accrue; to arise; to proceed; as, rents and profits issuing from land, tenements, or a capital stock.

(5): ( v. i.) To proceed, as progeny; to be derived; to be descended; to spring.

(6): ( v. i.) To proceed, as from a source; as, water issues from springs; light issues from the sun.

(7): ( v. i.) To go out; to rush out; to sally forth; as, troops issued from the town, and attacked the besiegers.

(8): ( v. i.) To extend; to pass or open; as, the path issues into the highway.

(9): ( v. i.) To pass or flow out; to run out, as from any inclosed place.

(10): ( n.) A point in debate or controversy on which the parties take affirmative and negative positions; a presentation of alternatives between which to choose or decide.

(11): ( n.) The final outcome or result; upshot; conclusion; event; hence, contest; test; trial.

(12): ( n.) An artificial ulcer, usually made in the fleshy part of the arm or leg, to produce the secretion and discharge of pus for the relief of some affected part.

(13): ( n.) A discharge of flux, as of blood.

(14): ( n.) Produce of the earth, or profits of land, tenements, or other property; as, A conveyed to B all his right for a term of years, with all the issues, rents, and profits.

(15): ( n.) Progeny; a child or children; offspring. In law, sometimes, in a general sense, all persons descended from a common ancestor; all lineal descendants.

(16): ( n.) That which passes, flows, or is sent out; the whole quantity sent forth or emitted at one time; as, an issue of bank notes; the daily issue of a newspaper.

(17): ( n.) The act of passing or flowing out; a moving out from any inclosed place; egress; as, the issue of water from a pipe, of blood from a wound, of air from a bellows, of people from a house.

(18): ( v. t.) To deliver for use; as, to issue provisions.

(19): ( n.) In pleading, a single material point of law or fact depending in the suit, which, being affirmed on the one side and denied on the other, is presented for determination. See General issue, under General, and Feigned issue, under Feigned.

(20): ( v. t.) To send out officially; to deliver by authority; as, to issue an order; to issue a writ.

(21): ( n.) The act of sending out, or causing to go forth; delivery; issuance; as, the issue of an order from a commanding officer; the issue of money from a treasury.

Vine's Expository Dictionary of NT Words [2]

A — 1: Ἔκβασις (Strong'S #1545 — Noun Feminine — ekbasis — ek'-bas-is )

"a way out," "way of escape,"  1—Corinthians 10:13 (ek, "out," baino, "to go"), is rendered "issue" in   Hebrews 13:7 , RV, for AV, "end," regarding the manner of life of deceased spiritual guides. See End.

A — 2: Ῥύσις (Strong'S #4511 — Noun Feminine — rhusis — hroo'-sis )

"a flowing" (akin to rheo, "to flow"), "an issue," is used in  Mark 5:25;  Luke 8:43,44 .

 Matthew 22:25

B — 1: Ἐκπορεύομαι (Strong'S #1607 — Verb — ekporeuo — ek-por-yoo'-om-ahee )

"to cause to go forth" (ek, "out," poreuo, "to cause to go"), is used in the Middle Voice in  Revelation 9:17,18 , of the coming forth of fire, smoke and brimstone from the mouths of the symbolic horses in a vision, AV, "issued" (the RV renders it by the verb "to proceed"). See Come , Depart , Go , Proceed.

King James Dictionary [3]

Issue n. ish'u.

1. The act of passing or flowing out a moving out of any inclosed place egress applied to water or other fluid, to smoke, to a body of men, &c. We say, an issue of water from a pipe, from a spring, or from a river an issue of blood from a wound, of air from a bellows an issue of people from a door or house. 2. A sending out as the issue of an order from a commanding officer or from a court the issue of money from a treasury. 3. Event consequence end or ultimate result. Our present condition will be best for us in the issue. 4. Passage out outlet.

To God the Lord belong the issues from death.  Psalms 68

5. Progeny a child or children offspring as, he had issue,a son and we speak of issue of the whole blood or half blood. A man dies without issue. 6. Produce of the earth, or profits of land, tenements or other property. A conveyed to B all his right to a term for years, with all the issues, rents and profits. 7. In surgery, a fontanel a little ulcer made in some part of an animal body, to promote discharges. 8. Evacuation discharge a flux or running. Lev 12Matt 9 9. In law, the close or result of pleadings the point of matter depending in suit, on which the parties join, and put the case to trial by a jury. 10. A giving out from a repository delivery as an issue of rations or provisions from a store, or of powder from a magazine.

Holman Bible Dictionary [4]

 Genesis 48:6 Isaiah 22:24 Matthew 22:25 2 Kings 20:18 Isaiah 39:7 Leviticus 15:2-15 Leviticus 15:19-24 Leviticus 15:25-30 Matthew 9:20 Ezekiel 23:20

Hastings' Dictionary of the Bible [5]

ISSUE . See Medicine, p. 600 a .

Cyclopedia of Biblical, Theological and Ecclesiastical Literature [6]

besides its ordinary sense of going forth ( נְגִד ,Chald. to Flow,  Daniel 7:10; also תּוֹצָאוֹת , Exit, i.e. source,  Proverbs 4:23, frequently of the direction or terminus of a boundary; Ἐκπορεύομαι , to Go Out,  Revelation 9:17-18), and Progeny מוֹלֶדֶת ,  Genesis 48:6, elsewhere;' kindred; צְפַיעוֹת , Shoots, i.e. offspring,  Isaiah 22:24; Σπέρμα , seed,  Matthew 22:25), is the rendering employed by our translators for several terms expressive of a purulent or unhealthy discharge, especially from the sexual organs. The most emphatic of these זוֹב , from זוּב , to Flow, both the verb and noun being frequently applied to diseased or unusual secretions, e.g. the monthly courses or Catanenia of women, and the seminal flux or Gonorrhea Benigra of men (Leviticus 15;  Numbers 5:2). (See Disease).

A more intense and chronic form of this discharge was the "issue of blood," or uterine hemorrhage of the woman in the Gospels ( Ῥύσυς Αἵματος ,  Mark 5:25;  Luke 8:43-44; Αἱμοῤῥέω ,  Matthew 9:20), which, as it made her ceremonially unclean, she was so anxious to conceal when she came in contact with the multitude and with Christ. (See monographs in Volbeding, Index, p. 49; Hase,-Leben Jesu, P. 141.). The term זַרְמָה ,  Ezekiel 23:20, signifies a pouring, and is applied to the emissio seminis of a stallion, to which the idolatrous paramours of Judaea are compared in the strong language of the prophet. (See Adultery). The only other term so rendered is מָקוֹר , a Fountain, applied to the womb, or Pudenda Muliebra, as the source of the menstrual discharge ( Leviticus 12:7;  Leviticus 20:18; comp. Πηγή ,  Mark 5:29). (See Flux).

"The texts  Leviticus 15:2-3;  Leviticus 22:4;  Numbers 5:2 (and  2 Samuel 3:29, where the malady is invoked as a curse), are probably to be interpreted of gonorrhea. In  Leviticus 15:3 a distinction is introduced, which merely means that the cessation of the actual flux does not constitute ceremonial cleanness, but that the patient must bide the legal time, seven days ( Leviticus 15:13), and perform the prescribed purifications and sacrifice ( Leviticus 15:14). See, however, Surenhusius's preface to the treatise Zabim of the Mishna, where another interpretation is given. As regards the specific varieties of this malady, it is generally asserted that its most severe form (gon. virulenta) is modern, having first appeared in the 15th century. Chardin (Voyages en Perse, 2, 200) states that he observed that this disorder was prevalent in Persia, but that its effects were far less severe than in Western climates.

If this be true, it would go some way to explain the alleged absence of the gon. virul. from ancient nosology, which found its field of observation in the East, Greece, etc., and to confirm the supposition that the milder form only was the subject of Mosaic legislation. But, beyond this, it is probable that diseases may appear, run their course, and disappear, and, for want of an accurate observation of their symptoms, leave no trace behind them. The bed,' seat,' etc. ( Leviticus 15:5-6, etc.), are not to be supposed to have been regarded by that law as contagious, but the defilement extended to them merely to give greater prominence to the ceremonial strictness with which the case was ruled. In the woman's issue,' (5. 19), the ordinary menstruation seems alone intended, supposed to be prolonged (5. 25) to a morbid - extent. The scriptural handling of the subject not dealing, as in the case of leprosy, in symptoms, it seems gratuitous to detail them here: those who desire such knowledge will find them in any compendium of therapeutics. See Josephus, War, 5, 5, 6; 6:9,3; Mishna, Chelim. 1, 3, 8; Maimon. ad Zabim, 2, 2: whence we learn that persons thus affected might not ascend the Temple mount, nor share in any religious celebration, nor even enter Jerusalem. See also Michaelis, Laws of Moses, 4:282" (Smith). (See Uncleanness).

International Standard Bible Encyclopedia [7]

ish´ū̇  :

(1) ( מולדת , mōledheth , צאצאים , ce'ĕcā'ı̄m  ; σπέρμα , spérma , "seed"): Offspring, descendants (  Genesis 48:6;  Isaiah 22:24;  Matthew 22:25 the King James Version).

(2) ( זרמה , zirmāh  ; יצא , yācā' (verb); ῥύσις , rhúsis ): A gushing of fluid (semen,   Ezekiel 23:20; water,  Ezekiel 47:8; blood,  Luke 8:43 ). See next article.