From BiblePortal Wikipedia

Webster's Dictionary [1]

(1): ( v. t.) To make desolate; to leave alone; to deprive of inhabitants; as, the earth was nearly desolated by the flood.

(2): ( a.) Destitute or deprived of inhabitants; deserted; uninhabited; hence, gloomy; as, a desolate isle; a desolate wilderness; a desolate house.

(3): ( a.) Laid waste; in a ruinous condition; neglected; destroyed; as, desolate altars.

(4): ( a.) Left alone; forsaken; lonely; comfortless.

(5): ( a.) Lost to shame; dissolute.

(6): ( a.) Destitute of; lacking in.

(7): ( v. t.) To lay waste; to ruin; to ravage; as, a fire desolates a city.

King James Dictionary [2]

Desolate a.

1. Destitute or deprived of inhabitants desert uninhabited denoting either stripped of inhabitants, or never having been inhabitated as a desolate isle a desolate wilderness.

I will make the cities of Judah desolate, without an inhabitant.  Jeremiah 9 .

2. Laid waste in a ruinous condition neglected destroyed as desolate altars desolate towers. Ezek. Zeph. 3. Solitary without a companion afflicted.

Tamar remained desolate in Absaloms house.  2 Samuel 13 .

4. Deserted of God deprived of comfort.

My heart within me is desolate.  Psalms 143 .

International Standard Bible Encyclopedia [3]

des´ō̇ - lā̇t (very frequently in the Old Testament for שׁמם , shāmēm , and its derivatives; less frequently, חרב , ḥārēbh , and its derivatives, and other words. In the New Testament it stands for ἔρημος , érēmos ( Matthew 23:38;  Acts 1:20;  Galatians 4:27 ) erēmóō ( Revelation 17:16 ), and monóō ( 1 Timothy 5:5 )): From Latin de , intens., solus , alone. Several shades of meaning can be distinguished: (1) Its primary sense is "left lonely," "forlorn," e.g.  Psalm 25:16 , "Have mercy upon me; for I am desolate" (Hebrew yāḥı̄dh , "alone");  1 Timothy 5:5 , "she that is a widow indeed, and desolate" (Greek memonōménē , "left alone"). (2) In the sense of "laid waste," "destitute of inhabitants," e.g.  Jeremiah 4:7 , "to make thy land desolate, that thy cities be laid waste, without inhabitant." (3) With the meaning "comfortless," "afflicted," e.g.  Psalm 143:4 , "My heart within me is desolate." (4) In the sense of "barren," "childless," "unfruitful," e.g.  Job 15:34;  Isaiah 49:21 (Hebrew galmūdh ).