Vine's Expository Dictionary of NT Words 
primarily, "to be behind, to be last," hence, "to lack, fail of, come short of," is translated "being destitute" in Hebrews 11:37 . See Behind , B, No. 1.
signifies "to leave, forsake;" in the Passive Voice, "to be left, forsaken, destitute;" in James 2:15 , AV, "destitute," RV, "be in lack." See Lack , Want.
Webster's Dictionary 
(1): ( v. t.) To make destitute; to cause to be in want; to deprive; - followed by of.
(2): ( a.) Forsaken; not having in possession (something necessary, or desirable); deficient; lacking; devoid; - often followed by of.
(3): ( a.) Not possessing the necessaries of life; in a condition of want; needy; without possessions or resources; very poor.
(4): ( v. t.) To leave destitute; to forsake; to abandon.
(5): ( v. t.) To disappoint.
King James Dictionary 
Destitute a. L. To set. Literally, set from or away.
1. Not having or possessing wanting as destitute of virtue, or of peity destitute of food and clothing. It differs from deprived, as it does not necessarily imply previous possession. 2. Needy abject comfortless friendless.
He will regard the prayer of the destitute. Psalms 102 .
DESTITUTE, n. One who is without friends or comfort.
1. To forsake. 2. To deprive.