Webster's Dictionary 
(1): ( superl.) Incapable of doing harm; no longer dangerous; in secure care or custody; as, the prisoner is safe.
(2): ( n.) A place for keeping things in safety.
(3): ( n.) A strong and fireproof receptacle (as a movable chest of steel, etc., or a closet or vault of brickwork) for containing money, valuable papers, or the like.
(4): ( superl.) Conferring safety; securing from harm; not exposing to danger; confining securely; to be relied upon; not dangerous; as, a safe harbor; a safe bridge, etc.
(5): ( n.) A ventilated or refrigerated chest or closet for securing provisions from noxious animals or insects.
(6): ( v. t.) To render safe; to make right.
(7): ( superl.) Free from harm, injury, or risk; untouched or unthreatened by danger or injury; unharmed; unhurt; secure; whole; as, safe from disease; safe from storms; safe from foes.
King James Dictionary 
1. Free from danger of any kind as safe from enemies safe from disease safe from storms safe from the malice of foes. 2. Free from hurt, injury or damage as, to walk safe over red hot plowshares. We brought the goods safe to land. 3. Conferring safety securing from harm as a safe guide a safe harbor a safe bridge. 4. Not exposing to danger. Philippians 3 . 5. No longer dangerous placed beyond the power of doing harm a ludicrous meaning.
Banquo's safe. - Aye, my good lord, safe in a ditch.
Safe, To render safe. Not in use.