Webster's Dictionary 
(1): ( adv.) In a rough manner; rudely; roughly.
(2): ( n.) Produced offhand.
(3): ( n.) Tossed in waves; boisterous; high; - said of a sea or other piece of water.
(4): ( n.) Boisterous weather.
(5): ( n.) Having inequalities, small ridges, or points, on the surface; not smooth or plain; as, a rough board; a rough stone; rough cloth.
(6): ( n.) A rude fellow; a coarse bully; a rowdy.
(7): ( v. t.) To cut or make in a hasty, rough manner; - with out; as, to rough out a carving, a sketch.
(8): ( n.) Hastily or carelessly done; wanting finish; incomplete; as, a rough estimate; a rough draught.
(9): ( n.) Tempestuous; boisterous; stormy; as, rough weather; a rough day.
(10): ( n.) Loud and hoarse; offensive to the ear; harsh; grating; - said of sound, voice, and the like; as, a rough tone; rough numbers.
(11): ( n.) Marked by severity or violence; harsh; hard; as, rough measures or actions.
(12): ( n.) Marked by coarseness; shaggy; ragged; disordered; - said of dress, appearance, or the like; as, a rough coat.
(13): ( n.) Hence, figuratively, lacking refinement, gentleness, or polish.
(14): ( v. t.) To render rough; to roughen.
(15): ( v. t.) To break in, as a horse, especially for military purposes.
(16): ( n.) Austere; harsh to the taste; as, rough wine.
(17): ( n.) Not polished; uncut; - said of a gem; as, a rough diamond.
(18): ( n.) Not level; having a broken surface; uneven; - said of a piece of land, or of a road.
(19): ( n.) Not courteous or kind; harsh; rude; uncivil; as, a rough temper.
Vine's Expository Dictionary of NT Words 
"rough, uneven," is used of paths, Luke 3:5; of rocky places, Acts 27:29 . See Rocky.
King James Dictionary 
ROUGH, a. L. raucus. Eng. rye, that is rough. L. ruga, a wrinkle. Gr. to snore. L. ruga, a wrinkle, a ridge. See Ridge. The primary sense is to stretch or strain but applied to roughness or wrinkling, it is to draw or contract, a straining together.
1. Having inequalities, small ridges or points on the surface not smooth or plane as a rough board, a rough stone rough cloth. 2. Stony abounding with stones and stumps as rough land or simply with stones as a rough road. 3. Not wrought or polished as a rough diamond. 4. Thrown into huge waves violently agitated as a rough sea. 5. Tempestuous stormy boisterous as rough weather. 6. Austere to the taste harsh as rough wine. 7. Harsh to the ear grating jarring unharmonious as rough sounds rough numbers. 8. Rugged of temper severe austere rude not mild or courteous.
A fiend, a fury, pitiless and rough.
9. Coarse in manners rude.
A surly boatman, rough as seas and wind.
10. Harsh violent not easy as a rough remedy. 11. Hard featured not delicate as a rough visage. 12. Harsh severe uncivil as rough usage. 13. Terrible dreadful.
On the rough edge of battle, ere it join'd, Satan advanc'd.
14. Rugged disordered in appearance coarse.
15. Hairy shaggy covered with hairs, bristles and the like.
Wilson's Dictionary of Bible Types 
Isaiah 40:4 (a) GOD will overcome difficult places in the life in order to make the way of life easy and happy for His child. He smoothes out the rocky road, brings down the hills and exalts the valleys to make life a blessing. (See Luke 3:5).