Despite

Webster's Dictionary

(1): ( n.) An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.

(2): ( n.) Malice; malignity; spite; malicious anger; contemptuous hate.

(3): ( n.) To vex; to annoy; to offend contemptuously.

(4): ( prep.) In spite of; against, or in defiance of; notwithstanding; as, despite his prejudices.

King James Dictionary

Despite, n.

1. Extreme malice violent hatred malignity malice irritated or enraged active malignity angry hatred.

With all thy despite against the land of israel.  Ezekiel 25 .

2. Defiance with contempt, or contempt of opposition.

He will rise to fame in despite of his enemies.